Here's my current top 5, (non-ordered, moment to moment they shift):
Twitterific
NetNewsWire
VLC
Toast
and the iPhone (it is a mac extension).

TIA for the Evernote invite.

BobB

Flow - Beautiful ftp with QuickView.

SketchUp - Quick, 3D sketching.

Moneydance - Like Microsoft Money for Mac ... and Windows ... and Linux.

Name Mangler - The one thing I can't believe Mac doesn't do on its own.

SimplyBurns - Simply burns. And Martin himself responds for support.

Extra Credit: Displaperture - Losing rounded menu bar corners was Leopard's biggest mistake.

1Password - For people with early Alzheimer like me!

Together - Organization software

Smultron - Code editor with the best price - Free!

Handbrake - to backup a DVD

NetNewsWire - RSS

TIA for the Evernote Beta invite!

Handbrake - to backup DVD

Mac the Ripper - to copy DVDs (I have little ones who like to run their own DVD player yet they scratch them up since they forget to put them back. So, I make copies for their use while I keep the original near me.)

Skype - VOIP calls

EyeTV - Records from TV

Bento - Organization

I like Handbrake, Mac the Ripper, twitterifc, twiddla, and netvibes.

TIA for the Evernote Beta invite!

I can't live without:

Quicksilver
NetNewsWire
Camino
1Password
Perian

These five are the first apps added to any system I use for more than 5 mins.

TIA for the Evernote Beta invite!

Only 2 left (reserved a couple for friends, sorry!).

Don't forget to share your invites too! Feel free to @babygotmac on twitter if you want to post your invite link.

Transmission
TvShows
VLC
mercury messenger
audio codex

Wow that could be great in the classroom....

Evernote sounded like a great idea until I played with it today and realized:

-The text recognition in photos is pretty poor. Evernote only recognized text in about 1 of every 10 of my photos. Not very reliable.

-Syncing with Evernote servers was constantly slow, and I began to feel uncomfortable thinking of my personal tidbits constantly streaming back and forth from a third-party server.

-'Paste to Evernote' created notes from whatever happened to be in my clipboard, not what I had highlighted on a web page, while "Clip screenshot" sometimes created a note of the screenshot, sometimes just a note consisting of the URL.

-Evernote drove me to "remember everything"--which is not really what we need. I was cataloguing every flower, but missing the whole field.

-I realized I was creating MORE work for myself. With Evernote, I would spend an ever greater amount of time tagging and SEARCHING through my info. Right now, when I have info to file, I put it where it belongs. Then if I need a photo, it's already there in iPhoto. I need an email address, it's already there in Address Book as I write an email. I need a website, it's already there in Bookmarks as I use Safari. Putting things where they belong in the first place guarantees they are exactly where you need them when you need them. When I need dinner, I usually find it in the fridge. When I need to grab shampoo, I don't have to hunt, it's always in the bathroom. Evernote is more like putting the entire contents of your home in one large plastic garbage bag--and when you need something, searching and fishing it out. I realized I would waste a lot of time SEARCHING through Evernote because I wouldn't know what I had or where I had it. Imagine 500 notes of business cards snapped in a webcam. This huge plastic garbage bag of tidbits and clippings and screen caps in my computer started to look pretty ugly. I don't need yet ANOTHER place to store and search for things. I'll keep my stuff organized how I have it now: Everything in its place.

If you have one left, I'd love one.

My top 5: Adobe Lightroom, AppZapper, Audio Hijac Pro, VMware Fusion, and VisualHub.